Quambone is a locality in New South Wales, Australia. Quambone is in the Coonamble Shire local government area, 591 kilometres (367 mi) north west of the state capital, Sydney and 56 kilometres (35 mi) west of Coonamble. The locality is centred at the junction of roads to Warren, Coonamble and Carinda. At the 2011 census, Quambone and the surrounding area had a population of 247.
It has a hotel/motel, general store and swimming pool, and a public school. It has regular Catholic and Anglican church services.
Doug Moppett, a long term member of the Parliament of New South Wales, lived at Quambone.