Angepena Station is a pastoral lease operating as a sheep station in South Australia.
The property is situated approximately 42 kilometres (26 mi) south east of Leigh Creek and 480 kilometres (298 mi) north of Adelaide.
The property was established in 1855 by John Baker who had applied for the Angepena and Pernunna leases the previous year. Baker appointed John Stewart to manage the property. The following year a hut-keeper employed at the property was murdered by Aborigines . After the attack Baker asked for police protection and a police station was built later the same year staffed by four troopers.
In 1888 Angepena occupied an area of 196 square miles (508 km2). It 1904 the owner was J. Snell. The Snell family still owned and resided at the property in 1966.
In 1966 the property was bought by Waraweena proprietors and was run by Mr and Mrs SW Nicholls.
In 2007 the station was placed on the market and was going to be sold to a youth support organization, Operation Flinders. The traditional owners of the area the Adnyamathanha peoples, who had been trying to buy a property in the region for the previous eight years, were devastated and asked the government to halt the sale. The sale was called off by Mr SW Nicholls and then sold to his son Mr & Mrs AS Nicholls.
The land occupying the extent of the Angepena pastoral lease was gazetted by the Government of South Australia as a locality in April 2013 under the name 'Angepena'.