Kalamurina Sanctuary is a nature reserve in arid north-eastern South Australia.
The 6,700 square kilometres (2,587 sq mi) pastoral lease operated as a cattle station for many decades in the 20th century. It was acquired in December 2007 by the Australian Wildlife Conservancy to become a nature reserve for biodiversity conservation and wildlife management. A high priority management need is a feral animal control program.
Although bordered by Cowarie Station to the east, the reserve is also between the Simpson Desert Regional Reserve to the north, Kati Thanda-Lake Eyre National Park to the south, the establishment of Kalamurina as a nature reserve creates a continuous protected area in central Australia larger than the State of Tasmania.