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Pascoe Vale South is a suburb of Melbourne, Victoria, Australia, 10 km north of Melbourne's central business district. Its local government area is the City of Moreland. At the 2016 Census, Pascoe Vale South had a population of 10,069.
Pascoe Vale South adjoins Brunswick West to the south, Strathmore and the Moonee Ponds Creek to the west, Coburg to the east, and Pascoe Vale to the north. The suburb also borders the Tullamarine Freeway.
Major features of the suburb include the Bell Street/Melville Road Shopping area.